Meaney's career spanned 30 years. The father and native New Yorker had a small role as an executive in the 1988 film comedy "Big," starring Tom Hanks, and helmed the CBS version of "Uncle Buck," which ran just one season, from 1990 to 1991.
It was his first HBO special, in 1986, that launched his comedy career after he toiled doing standup in San Francisco and Boston. In 1987, he took his first turn on "The Tonight Show with Johnny Carson." He also appeared as a guest on "Saturday Night Live" and on shows including those hosted by David Letterman, Oprah Winfrey and Conan O'Brien.